Mixing Technology for Pharmaceutical Products

Agitators and Vacuum Processing Units

Decades of know-how in dispersing and mixing technology as well as depth knowledge in all disciplines of process engineering at EKATO GROUP form the basis for the successful use of EKATO technology in the pharmaceutical industry.
Pharmaceutical products place a unique set of demands on agitators. The highest standards must be met. This applies to hygiene, the specialized processes employed, and the certified systems in use. Companies from the pharmaceutical industry benefit from EKATO SYSTEMS’ many years of experience and vast expertise in the production of equipment for the personal care and healthcare industry. In addition to the dryers and mixers offered in the product portfolio of SOLIDMIX, e.g. to dry active pharmaceutical substances, the product basket of UNIMIX covers the production of ointments, creams and gels that are used in the pharmaceutical industry. Reproducibility with respect to the production of pharmaceutical products is ensured based on system components that have been developed applying engineering expertise. Its mixers and dispersers in particular have been designed to ensure product stability and a uniform distribution of APIs in the product. Agitator systems play a central role in the production of APIs. The biotechnological production and hydrogenation of intermediate and finished products also place unique demands on the agitator systems. EKATO Rühr- und Mischtechnik GmbH works in the field of hydrogenation for over 85 years and offers specially designed hydrogenation plants for pharmaceutical applications.

In addition to the challenging tasks of active pharmaceutical ingredient synthesis production, the EKATO GROUP can also cover the area of industrial agitators in the pharmaceutical industry through the mixing and dispersing technology of FLUID Misch- und Dispergiertechnik GmbH. Mixing tasks can be suspending solids in a liquid phase, heating and cooling or mixing liquids. These mixing tasks are often part of the starting materials or storage of intermediate and final products.

Scale-up capability of the technology is crucial. To achieve this, algorithms are applied that have been specifically developed and verified many times. The systems and equipment are subjected to an established certification process to ensure top product quality.

Typical Project Process Flow

  • Concept phase
  • Design phase
  • Execution- and manufacturing phases
  • Test phase

We support by our consulting competencies in all project phases beginning from an URS to a functional specification, execution specification, production and installation of the plant, including the necessary qualification, for example

  • Design Qualification (DQ)
  • Installation Qualification (IQ)
  • Operational Qualification (OQ)
  • Support during Performance Qualification (PQ)

A crucial point is an early involvement and integration to the customers projects process to deliver the right package fitting customers’ needs.